刘 艳 副教授, 硕士生导师
北京市海淀区学院路38号，邮编 100191
Tel: (+8610) 82801508
Email: yanliu@bjmu.edu.cn
1986年在山东大学化学系获得理学学士学位。1989年在山东大学化学系获得理学硕士学位。同年8月到北京医科大学药学院工作。1998-2000年到德国雷根斯堡大学化学与药学系工作与学习。2000年至今，任北京大学药学院药剂学系副教授。讲授物理化学、物理药剂学和分散体系的物理化学等本科、硕士和博士研究生课程。担任《化学学报》、《药学学报》、《中国药学杂志》、《中国新药杂志》、Biomaterials、Acta、Biomaterialia、Biomacromolecules、Molecular Pharmaceutics、International Journal of Pharmaceutics、Pharmaceutical Research等多个学术期刊的评审。主持或参加的基金项目包括国家自然科学基金、973重大研究计划、国家重大新药创制专项新剂型与新释药系统技术平台等。在国内、外学术期刊上发表论文80余篇。主编教材或专著6部，主译专著1部，参编教材4部。申请国家发明专利15项,8项专利已获得授权。主持完成了数个药物制剂的研究开发工作。
研究兴趣
物理药剂学。主要涉及以下研究领域
1. 新型纳米载体系统与靶向给药
2. 功能高分子材料与智能释药系统
3. 药物多晶型
代表性论文
1. Yajie Gao, Yanfang Li, Yushu Li, Yan Liu*, et al. PSMA-mediated endosome escape-accelerating polymeric micelles for targeted therapy ofprostate cancerand the real time tracing of their intracellular trafficking. Nanoscale, 2015, 7(2):597-612.
2.Jinwen Li, Yanxia Zhou, Chengwei Li, Yan Liu*, et al. Poly(2-ethyl-2-oxazoline)-doxorubicin conjugate-based dual endosomal pH-sensitive micelles with enhanced antitumor efficacy. Bioconjugate Chemistry, 2015, 26(1):110-119.
3.Yong Zhao, Yanxia Zhou, Dishi Wang, Yan Liu*, et al.pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) for tumor-targeting and controlled delivery ofdoxorubicin and P-gp inhibitor.Acta Biomaterialia, 2015,17:182-192.
4. Yajie Gao, Chao Zhang, Yanxia Zhou, Yan Liu*, et al. Endosomal pH-responsive polymer-based dual-ligand-modified micellar nanoparticles for tumor targeted delivery and facilitated intracellular releaseof paclitaxel. Pharmaceutical Research, 2015, 32(8):2649-2662.
5. Lei Zhao, Yanxia Zhou, Yajie Gao,Yan Liu*, et al.Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. International Journal of Pharmaceutics, 2015, 483:180-187.
6. Yajie Gao, Yanxia Zhou, Lei Zhao, Yan Liu*, et al. Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles. Acta Biomaterialia, 2015, 23:127-135.
7. Wenjing Li, Xinru Li, Yajie Gao, Yan Liu*, et al. The Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity. Molecular Pharmaceutics,2014,11:71-80.
8. Chao Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Enhancedtopical delivery of tetrandrine by ethosomes for treatment of arthritis. Journal of Biomedicine and Biotechnology, 2013, Article ID 161943.
9. Na Li, Xinru Li, Yanxia Zhou, Yan Liu*, et al. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier. Biomaterials, 2012, 33(34):8881-8892.
10. Guiling Li, Yating Fan, Xinru Li, Yan Liu*, et al. In vitro and in vivo evaluation of a simple microemulsion formulation for propofol. International Journal of Pharmaceutics, 2012, 425:53–61.
11. Guiling Li, Chao Fan, Xinru Li, Yan Liu*, et al. Preparation and in vitro evaluation of tacrolimus loaded ethosomes. The Scientific World Journal, 2012, Article ID 874053.
12. Guiling Li, Yating Fan, Chao Fan, Yan Liu*, et al. Tacrolimus-loaded ethosomes: Physicochemical characterization and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 2012, 82:49-57.
13. Xingwei Chen, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization and in vivo evaluation. Journal of Biomaterials Applications, 2012, 27(4): 391-402.
14. Xiaoning Wang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels. Acta Biomaterialia, 2011, 7: 4149-4159.
15. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu*, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics, 2011, 407:158-166.
16. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu*, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters, 2011, 6:275.
17. Yating Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. International Journal of Pharmaceutics,2011, 416:323-330.
18. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid) micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics, 2010, 7(4):1169-1182.
19. Wang Fei, Li Xinru, Zhou Yanxia, Yan Liu*, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics, 2010, 7(3):718-726.
20. Xinru Li, Pingzhu Li, Yan Liu*, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously.Pharmaceutical Research, 2010, 27(8):1498-1511.
21. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu*, et al. Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799.
22. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Preparation and evaluation of poly(ethylene glycol)–poly(Lactide) micelles as nanocarriers for oral Deliveryof cyclosporine A. Nanoscale Resrarch Letters, 2010, 5:917-925.
23. Xinru Li, Quan Yuan, Yanqing Huang, Yan Liu*, et al.Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech, 2010, 11(2):672-678.
24. Ming Chen , Xin-Ru Li, Yan-Xia Zhou,Yan Liu*, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides, 2009,30:1288-1295.
25. Kewei Yang, Xinru Li, Zhuoli Yang, Yan Liu*, et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization. Journal of Biomedical Materials Research Part A,2009, 87(4):140-148.
26. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu*, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting, 2009, 17(10):739-750.
27. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu*, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters, 2009, 4:1502-1511.
28. Zhuoli Yang, Xinru Li, Kewei Yang, Yan Liu*. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: preparation, freeze-drying and in vitro release. Journal of Biomedical Materials Research Part A, 2008, 85(2):539-546.
