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王学清 副教授
发布日期:2016-01-26 浏览次数: 字号:[ ]

王学清博士,副教授,硕士研究生导师

 

电话:010-82805935, 电子信箱:wangxq@bjmu.edu.cn

1989.9-1993.7 北京医科大学药学专业学习,获学士学位。2001.9-2003.7年于北京大学药剂学专业在职学习,获硕士学位。2005.9-2008.7年于中国科学院生物物理研究所在职学习,获博士学位。2011年于奥地利因斯布鲁克大学进修学习三个月。1993.8留校后进入北京医科大学药学院药剂教研室从事教学和科研工作,主要承担本科生、研究生的药剂学、生物药剂学与药物动力学的理论课程与实验课程的教学工作。1998年聘为讲师,2009年聘为副教授。

主持或参与多项国家课题和新药制剂开发工作,如国家自然科学基金面上项目“受体介导的纳米载体在极性上皮细胞的跨膜转运机理研究”(主持,在研),“新型预活化巯基化聚合物促进蛋白多肽药物跨膜转运机理研究”(主持,在研)、国家自然科学基金-海外及港澳学者合作研究基金“细胞和斑马鱼模型评价纳米制剂的跨膜转运机理和体内过程”(合作者,在研),NSF重点资助项目“基于分子靶向给药的肿瘤联合治疗”(参加,在研)、973计划资助项目“难溶性药物口服纳米制剂的转运机制及临床转化研究”(PI,在研),“纳米技术改善难溶性药物功效的应用基础研究”(PI,已结题)、科技部“重大新药创制”新制剂与新释药系统技术平台建设项目(已结题)、863计划资助项目“环孢素A纳米粒口服剂型的研究”(已结题)、NSF重点资助项目“载体给药系统的分子药剂学”(已结题)、“蚯蚓纤连蛋白酶在乙型肝炎治疗中的基础研究”、一类新药“RS-27 输液剂的研制”等。

已在国内外刊物发表学术论文100余篇,申请专利5项,多次参编《药剂学》,《生物药剂学与药物动力学》以及执业药师培训的相关教材。2003年获得教育部自然科学奖2等奖(新型纳米给药系统的研究,第五完成人);2009年获得教育部自然科学奖1等奖(抗肿瘤与肿瘤干细胞多药耐药性长循环载药脂质体给药系统的研究,第七完成人);2012年获教育部自然科学一等奖(基于分子靶的新型抗肿瘤分子靶向递送系统研究,第八完成人)。目前担任多个国内外期刊杂志的审稿人。

主要研究方向

1.      纳米技术增加难溶性药物及蛋白多肽药物的口服吸收;

2.      肿瘤靶向纳米药物输送系统研究。

代表性论文

1. Qin Song, Xing Wang, Yaoqi Wang, Yanqin Liang, Yanxia Zhou, Xiaoning Song, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. Reduction responsive self-assembled nanoparticles based on disulfide-linked drug-drug conjugate with high drug loading and antitumor efficacy. Molecular Pharmaceutics. 2016, 13, 190-201 .

2. Xianhui Chen, Yang Zhang, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, Qiang Zhang. The P-glycoprotein inhibitory effect and related mechanisms of thiolated chitosan and its S-protected derivative. RSC Advances. 2015, 5, 104228–104238.

3. Hua Zhang, Hongxiang Hu, Haoran Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang* and Qiang Zhang*. Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis. Nanoscale. 2015, 7, 10790–10800.

4. Feiyang Deng, Chao Yu, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang*, Qiang Zhang. The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transportation in rats. Current Drug Delivery.  On line 2015 Jul 22.

5. Qin Song, Xingxing Chuan, Binlong Chen, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells . Drug Delivery. DOI: 10.3109/10717544.2015.1028601

6. Hua Zhang, Youyou Zhao, Xueqing Wang*, and Qiang Zhang. Bioavailability of tramadol hydrochloride after administration via different routes in rats. Biopharmaceutics & Drug Disposition. 2014, 35: 525–531.

7. Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, and Qiang Zhang. Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)?Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo. Molecular Pharmaceutics. 2014, 11, 3656?3670.

8. Xueqing Wang, Suxin Li, Yujie Shi, Xingxing Chuan, Ji Li, Ting Zhong, Hua Zhang, Wenbing Dai, Bing He, Qing Zhang *.The development of site-specific drug delivery nanocarriers based on receptor mediation. Journal of Controlled Release. 2014, 193: 139-153.

9. Jingkai Lu, Xingxing Chuan, Hua Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang*, Qiang Zhang*. Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo.  International Journal of Pharmaceutics. 2014, 471 (1-2) 525–535.

10. 杨建胜,陈显慧,张华,代文兵,王学清*,张强。稳定化巯基化聚合物PAA-Cys-6MNA 的合成与促渗透功能研究。药学学报,2014, 49 (6): 942?948

11. Chao Yu, Bing He, Meng-Hua Xiong, Hua Zhang, Lan Yuan, Ling Ma, Wen-Bing Dai, Jun Wang, Xing-Lin Wang, Xueqing Wang*, Qiang Zhang*, The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cell. Biomaterials. 201334 (26): 6284-6298.

12. Bo Zhao, Xueqing Wang*, Xiao-You Wang, Hua Zhang, Wen-Bing Dai, Jun Wang, Zhen-Lin Zhong, Hou-Nan Wu* and Qiang Zhang*. Nanotoxicity comparison of four amphiphilic polymeric micelles with similar hydrophilic or hydrophobic structure. Particle and Fibre Toxicology. 2013, 10:47.

13. 于超,何冰,张华,代文兵,王学清*,张强。载香豆素6 PEG-PCL 胶束跨MDCK 极性上皮细胞的转运过程。药学学报,2013, 48 (9): 1484 ?1490

14. 赵波,范俣辰,王学清*,代文兵,张*,王杏林。iRGD 修饰的阿霉素主动靶向脂质体的细胞毒与抗肿瘤效果评价。药学学报,2013, 48 (3): 417-422

15. 杨爱华,张华,章俊麟,金武,王学清*,张强。维生素A 修饰的阿霉素隐形脂质体对肝星状细胞的靶向性。中国新药杂志,2013, 22 (15): 1797-1801

16. 串星星,王学清*,张强。还原敏感型聚合物胶束在肿瘤靶向药物递送中的应用。中国药学杂志,201348 (24): 2069-2075

17.Wang X Q, Zhang Q. Microemulsions for Drug Solubilization and Delivery [J]. Drug Delivery Strategies for Poorly Water-Soluble Drugs. 2012: 287-323.

18. Xueqing Wang, Javed Iqbal, Deni Rahmat, Andreas Bernkop-Schnürch*. Preactivated thiomers: Permeation enhancing properties. International Journal of Pharmaceutics. 2012, 438 (1-2): 217-224.

19. Xueqing Wang, Qiang Zhang*. pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics. 2012, 82 (2): 219-229.

20. Xueqing Wang, Jie-ming Fan, Ya-ou Liu, Bo Zhao, Zeng-rong Jia, Qiang Zhang. Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat. International Journal of Pharmaceutics 2011. 419 (1-2): 339–346.

21. Ya-Ou Liu, Jie-Ming Fan, Xueqing Wang*, Qiang Zhang. Preparation of sorafenib selfmicroemulsifying drug delivery system and its relative bioavailability in rats. Journal of Chinese Pharmaceutical Sciences. 2011, 20: 164-170.

22. 王学清,张源,潘荣,赫荣乔。蚯蚓纤溶酶口服后在大鼠胃肠道的转运分布特点。中国新药杂志,20101915):1360-1364

23. Xueqing Wang, Lan Chen, Rong Pan, Jing Zhao, Ying Liu, Rong-Qiao He, An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells. BMC biochemistry. 2008, 9:30 doi:10.1186/1471-2091-9-30.

24. Xueqing Wang, Jun-Dong Dai, Hua Zhang, Xuan Zhang,Jian-Cheng Wang, Qiang Zhang*. Absorption mechanism of cyclosporine A loaded pH-sensitive nanoparticles in rats. Journal of Nanoscience and Nanotechnology. 2008, 8: 2422-2431.

25. Xueqing Wang, Jia Huang, Jun-dong Dai, Tao Zhang, Wan-liang Lu,Hua Zhang, Xuan Zhang, Jian-cheng Wang, Qiang Zhang*. Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid. International Journal of Pharmaceutics. 2006, 322: 146-153.

26. Xueqing Wang, Jun-dong Dai, Zhen Chen, Tao Zhang, Gui-min Xia, Qiang Zhang*. Bioavailability and Pharmacokinetics of Cyclosporine A loaded pH-sensitive nanoparticles for oral administration. Journal of Controlled Release. 2004, 97: 421-429.

27. 王学清,张涛,贺颖,章亮,张强*。环孢素A聚乳酸纳米粒胶体的制备与大鼠生物利用度的测定。药学学报,2004391):68-71

28. 王学清,戴俊东,张强*,张涛,夏桂民。环孢素A-羟丙甲纤维素酞酸酯纳米粒的大鼠相对生物利用度。药学学报,2004396):463-466

29. 王学清,陈真,戴俊东,张涛,夏桂民,张强*。不同助悬剂对环孢素A 羟丙甲纤维素酞酸酯纳米粒大鼠口服后体内相对生物利用度的影响。北京大学学报(医学版),2004363):305-308

30王学清,齐宪荣*,刘明辉。盐酸丁卡因脂质体凝胶的制备与释放度的测定。中国现代应用药学,2003201):37-40

31王学清,齐宪荣*,刘跃鹏。盐酸丁卡因脂质体凝胶剂经皮渗透性。北京大学学报医学版,2002344):365-367375

32王学清,齐宪荣*,张强。提高硝酸甘油舌下片稳定性的方法。中华临床医药杂志,200233):17-19

代表性专利

1.张强,王学清,戴俊东,周田彦。“供口服的肠溶性纳米粒给药系统”。(国家发明专利公开号:CN1418703,授权公告号:CN 1233413C)。

2.赫荣乔,王学清,陈岚,潘荣,肖蓉。“蚯蚓纤连蛋白酶在乙型肝炎治疗中的应用”。(国家发明专利申请号:200810101356.9;授权公告号:CN 101525610 B)。

3王学清,刘亚欧,孙佳妮,范洁明,张强。“一种供口服或静脉注射用索拉非尼自微乳化给药系统及其制备方法”。(国家发明专利申请号:200910203734.9,授权公告号CN 101584661 B)。

4王学清;串星星;张强;张华;代文兵;宋钦。一种还原响应型聚乙二醇化药物纳米组合物的制备及应用。专利申请号:201410003163.5

5. 王学清;宋钦;张强;张华;代文兵。一种还原响应型药物偶联物纳米粒的制备及其应用。专利申请号:201510053565.0

 (2016-01-09更新)




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