周田彦 博士 教授 硕士生导师
电话：(10)-82805937
电子信箱：tianyanzhou@bjmu.edu.cn
简历
分别于1992年、1998年在北京医科大学药学院获得学士和硕士学位，1998年留校至今一直在北京大学药学院药剂教研室工作，并于2006年取得药剂学博士学位。曾到香港理工大学(2002-2004)和美国奥克拉荷马州立大学(2007-2008)作访问研究。现任北京大学药学院教授、硕士生导师、中国药理学会定量药理学专业委员会委员。
主持了北京大学药学院青年启动基金，教育部留学回国人员启动基金以及国家自然科学基金等项目，是北京大学创新药物平台代谢子平台的骨干成员。担任国家自然科学基金等项目的评审专家。获得奖励主要包括北京大学医学部教学优秀奖(2013、2010)，北京大学医学部优秀青年学者(2010)，教育部“高等学校科学技术奖”自然科学二等奖(2006)，北京大学医学部优秀SCI论文三等奖(2004)等。担任《中国临床药理学与治疗学》编委，以及中国药学杂志、中国药学(英文版)、Expert Opinion On Drug Metabolism and Toxicology, Acta Pharmacologica Sinica, Cancer Chemotherapy and Pharmacology, PLoS One, Current Analytical Chemistry等学术期刊的评审。
在国内外发表论文70余篇，编写教材与专著6部，申请专利3项。主讲本科生《生物药剂学与药物动力学》以及研究生《药物动力学》、《高等药物动力学》等课程。
研究领域与兴趣
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基于机制的药物动力学/药效动力学
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药物代谢酶的调控机理及功能
Tianyan Zhou, PhD, Professor
Department of Pharmaceutics
School of Pharmaceutical Sciences
Peking University
Beijing, 100191, P. R. China
Tel: 86-10-82805937
E-mail: tianyanzhou@bjmu.edu.cn
Tianyan Zhou received her Bachelor, Master, and PhD degree from School of Pharmaceutical Sciences, Beijing Medical University/Peking University in 1992, 1998, and 2006, respectively. She worked as Lecturer in Sept 1999, promoted as Associate professor in Aug 2005, and then Full Professor in Aug 2015 in Peking University. From Aug 2002 to Sept 2004, she worked as Research Associate in The Hong Kong Polytechnic University. From Feb 2007 to Aug 2008, she worked as Visiting Scholar in Oklahoma State University in USA.
She is a committee member of Professional Committee of Pharmacometrics of Chinese Pharmacological Society, as well as the principle investigator on Natural Science Foundation of China Grant and the Grant for the Returned Overseas Scholars of Ministry of Education, the editorial board of Chinese Clinical Pharmacology and Therapeutics, and the referee for some journals related to pharmacokinetic/ pharmacodynamic and cancer research sciences. She has published more than 70 research papers and 6 book chapters, and has applied 3 patents. Her teaching courses include Biopharmaceutics and Pharmacokinetics (undergraduate course), Pharmacokinetics (Master/PhD course), and Advanced Pharmacokinetics (Master/PhD course).
Research Interests
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Mechanism-based Pharmacokinetics/Pharmacodynamics modeling and simulation
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Regulation mechanisms of drug metabolizing enzymes and their applications
Selected Publications（发表的部分论文）
1. Yuan, Y; Zhou, X; Ren, YP; Zhou, SP, Wang, LJ; Ji, SM; Hua, M; Li L; Lu, W; Zhou, TY*. Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer. J Pharm Sci. 2015, 104, 4399–4408.
2. Wang, SY; Mou, ZZ; Ma, YH; Li, J; Li, JY; Ji, XW; Wu, KH; Li, L; Lu, W; Zhou, TY*. Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: involvement of eradicating cancer stem-like cells. Biochem Pharmacol. 2015 May, 95(2), 98-109.
3. Ji, XW; Zhou, TY; Lu, Y; Wei, MJ, Lu; W; Cho, William Cs. Breast cancer treatment and sulfotransferase. Expert Opinion on Therapeutic Targets. 2015 Jun, 19(6), 821-34.
4. Ji, XW; Chen, GP; Song, Y; Li, L; Yuan, Y; Wang, SY; Zhou, TY*; Lu, W. Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208. Acta Pharmacol Sin. 2015 OCT, 36, 1246-55.
5. Li, J; Ji, XW; Yuan, Y; Fan, R; Shao, XY; Su, QH; Wang, SY; Li, L; Zhou, TY*; Lu, W. A simple LC-MS/MS method for the determination of moxifloxacin N-sulfate in rat plasma and its application to a pharmacokinetic study. J AOAC INT. 2015 July, 98(4), 921-926.
6. Li, JY; Li, J; Wang, SY; Yuan, Y; Su, QH; Lu, W; Zhou, TY*. Simultaneous determination of sunitinib and its active metabolites N-desethylsunitinib (SU12662) in nude mice plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. J Chinese Pharm Sci. 2015, April, 24(4), 217-224.
7. Yuan, Y; Zhou, X; Li, J; Ye, S., Ji, XW; Li, L; Zhou, TY*; and Lu, W. Development and validation of a highly sensitive LC-MS/MS method for the determination of dexamethasone in nude mice plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2015 Apr, 29(4), 578-83.
8. Shao, XY; Li, J; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W; Zhou, TY*. Exogenous dopamine induces dehydroepiandrosterone sulfotranferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats. Drug Metab Pharmacok. 2015 Jan, 30, 97-104.
9. Li, XG; Zhao, ZG; Li, L; Zhou, TY*; and Lu, W*. Pharmacokinetics, in vitro and in vivo correlation, and efficacy of exenatide microspheres in diabetic rats. Drug Deliv. 2015 Jan, 22(1), 86–93.
10. Shao, XY; Li, J; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W; Zhou, TY*. Comparison of dopamine with levodopa in the induction of aryl sulfotransferases and estrogen sulfotransferase in rat liver. J Chinese Pharm Sci. 2014 Jul, 23(7), 471-479.
11. Xu, JJ; Wang, SY; Chen, Y; Chen, GP; Li ZQ; Shao, XY; Li, L; Lu, W; Zhou, TY*. Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. Acta Pharmacol Sin. 2014, 35(7), 889-898.
12. Ji, XW; Li, RT; Li, ZQ; Li, L; Shao, XY; Wang, SY; Yuan, Y; Zhou, TY*; Lu, W*. Inhibition of autophosphorylation of EGFR plays an important role in the anti-breast cancer efficacy of a dithiocarbamate derivative TM208. Acta Pharmacol Sin. 2014, 35, 239–247.
13. Li, MY; Li, HQ; Cheng, XL; Wang, XP; Li, L; Zhou, TY*, and Lu, W*. Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction between Erlotinib and Gemcitabine. Pharm Res. 2013, 30, 1400-1408.
14. Zhou, TY; Huang, CQ; Chen, Y; Xu, JJ; Shanbhag, PD; Chen, GP. Methamphetamine Regulation of Sulfotransferase 1A1 and 2A1 Expression in Rat Brain Sections. Neurotoxicology. 2013, 34, 212-218.
15. Wu, Q; Li, MY; Li, HQ; Deng, CH; Li, L; Zhou, TY*, and Lu, W*. Pharmacokinetic and pharmacodynamic study of erlotinib based upon phosphorylated epidermal growth factor receptor and tumor volume in human non-small cell lung cancer xenograft mouse mode. Acta Pharmacol Sin. 2013, 34, 1427–1436.
16. Cheng, XL; Guo,LP; Li, ZQ; Li, L; Zhou, TY*, Lu, W*. A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study. J Chromatogr B. 2013, 915–916, 64–70.
17. Zhou, TY; Chen, Y; Huang, CQ; Chen, GP. Caffeine induction of sulfotransferases in rat liver and intestine. J Appl Toxicol. 2012, 32, 804-809.
18. Zhou, X; Shang, DW; Zhang, TL; Li, L; Zhou, TY*; Lu, W*. Modeling of Angiotensin II-Angiotensin-(1-7) Counterbalance in Disease Progression in Spontaneously Hypertensive Rats Treated With/Without Perindopril. Pharmacol Res. 2012, 66, 177-184.
19. Li, XG; Li, L; Wang, XP; Ren, YP; Zhou, TY*; Lu, W*. Application of Model-Based Methods to Characterize Exenatide-Loaded Double-Walled Microspheres: In Vivo Release, Pharmacokinetic/Pharmacodynamic Model, and In Vitro and In Vivo Correlation. J Pharm Sci. 2012, 101, 3946-3961.
20. Xu, JJ; Chen, Y; Li, L; Li, ZQ; Wang, CA; Zhou, TY*, Lu, W*. An improved HPLC method for the quantitation of 3′-phosphoadenosine 5′-phosphate (PAP) to assay sulfotransferase enzyme activity in HepG2 cells. J Pharmaceut Biomed Analysis. 2012, 62, 182-186.
21. Ji, XW; Chen, Y; Li, RT; Zhou, TY*; Lu, W*. A high-sensitivity LC-MS/MS method for determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenylpropyl ester hydrochloride in rat plasma and its application to pharmacokinetics study. Biomed Chromatogr. 2012, 26, 1196-1201.
22. Li, XG; Li,L; Zhou,X; Chen,Y; Ren,YP; Zhou, TY*; Lu, W*. Pharmacokinetic/pharmacodynamic studies for exenatide in diabetic rats. Acta Pharmacol Sin. 2012, 33, 1379-1386.
23. Li, L; Li, ZQ; Deng, CH; Ning, MR; Li, HQ; Bi, SS; Zhou, TY* and Lu, W*. Mechanism-based Pharmacokinetic/Pharmacodynamic Model for CYP3A1/2 Induction by Dexamethasone in Rats. Acta Pharmacol Sin. 2012, 33, 127-136.
24. Li, MY; Wu, Q; Li, HQ; Ning, MR; Chen, Y; Li, L; Zhou, TY*; and Lu, W*. A high-sensitive LC-MS/MS method to determine the concentrations of erlotinib and its active metabolite OSI-420 in BALB/c nude mice simultaneously and its application to a pharmacokinetic study. J Chin Pharm Sci. 2012, 21, 296-303.
25. Chen, Y; Li, HQ; Xu, JJ; Jiu, XF; Deng, CH; Li, XG; Li, L; Xu, XQ; Zhou, TY*; and Lu, W*. Determination of metformin in diabetic rat plasma by an improved ion-pair high-performance liquid chromatography: Application to pharmacokinetic study, J Chin Pharm Sci. 2012, 21, 211-218.
26. Ning, MR; Li, L; Li, J; Li, ZQ; Li, RT; Zhou, TY*; Lu, W*. In-vitro screen of reversible and time-dependent inhibition of CYP3A by TM208 and TM209 in rat liver microsomes. Acta Pharm Sin B. 2012, 2, 179-185.
27. Shang, DW; Wang, XP; Zhao, XT; Huang, FM; Tian, GZ; Lu, W*; Zhou, TY*. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. J Chromatogr B. 2011, 879, 3459-3464．
28. Li, HQ; Li, MY; Li, ZQ; Li, L; Bi, SS; Deng, CH; Chen, R; Zhou,TY* and Lu, W*. New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines. Chin J Chem, 2011, 29, 1709-1714.
29. Jiu, XF; Shang, DW; Chen, Y; Li, XG; Wan, XM; Zhou, TY*; Lu, W*. A high performance liquid chromatography method for the quantitative determination assay of sitagliptin in rat plasma and its application in pharmacokinetics study. J Chin Pharm Sci. 2011, 20, 63-69.
30. Li, L; Li, ZQ; Li,HQ; Bi, SS; Li, Bo; Xu, JJ; Zhou, TY* and Lu, W*. Development of a quantitative real time PCR assay for absolute detection and quantification of CYP3A1 and CYP3A2 mRNA induction in rat liver. J Chin Pharm Sci. 2011, 20, 597-603.
31. Li, HQ; Chen, Y; Li, ZQ; Deng, CH; Li, L; Bi, SS; Li, MY; Zhou, TY*; Lu, W*. A high performance liquid chromatography method for the quantitative determination of erlotinib in the plasma of tumor bearing BALB/c nude mice and its application in a pharmacokinetic study. J Chin Pharm Sci. 2011, 20, 245-252.
32. Zhou, TY; Huang, CQ; Chen, Y; Shanbhag, PD; Chen, GP. Methamphetamine regulation of sulfotransferases in rat liver and brain. Am J Pharmacol Toxicol, 2010, 5, 125-132.
33. Zhou, TY; Li, XM; Ng, MTT; Wang, YF; Quek, NM; Luo, J; Yuan, WX; Tan, CH; Zeng, HQ; Li, TH. Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chem, 2009, 20, 644-647.
34. Zhou, TY; Wang, YF; Li, XM; Zhang, Q; Li, TH. Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. B Chem Soc Jpn, 2006, 79(8), 1300-1302.
35. Zhou, TY; Chen, GS; Wang, YF; Zhang, Q; Yang, M; Li, TH. Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Res.2004, 32, e173/1-e173/9.
