Professor Xuan Zhang, PhD
Department of Pharmaceutics
School of Pharmaceutical Sciences
Peking University
Beijing 100191, China
Tel : +8610 8280 5928 (office)
Email: xuanzhang@bjmu.edu.cn
Received his bachelor (1990), master (1993) and doctor degree (1999) from Department of Pharmaceutical Sciences, China Pharmaceutical University.
Engaged in his postdoctoral fellow in School of Pharmaceutical Sciences, Peking University from 1999 to 2001.
As a visiting scholar in Stockholm University (Sweden 2004-2005) and Kyushu University (Japan 2006).
Been working in School of Pharmaceutical Sciences, Peking University since 2001.
He is engaged in teaching and research work of pharmaceutics. His teaching courses including pharmaceutics, biopharmaceutics and pharmacokinetics, pharmacy literature, advanced in pharmaceutics for undergraduate or graduate students.
Published more than thirty research papers and five 5 textbooks. Applied four patents, two of them have been authorized.
Editor of Journal of Chinese Pharmaceutical Sciences, Reviewer of some international journals.
Research interesting:
Drug delivery system
Awards
1. “Novel drug delivery system” Science and Technology Progress Award from Chinese Pharmaceutical Association in 2008, First Prize, Second Order.
2. “Novel nano-drug delivery system” Award for Natural Sciences from Ministry of Education in 2004, Second Prize, Second Order.
3. “Novel protein drug delivery system” Award for Natural Sciences from Ministry of Education in 2002, Second Prize, Second Order.
4. “Long circulation liposomes for anti-cancer delivery system” Award for Natural Sciences from Ministry of Education in 2010, First Prize, Fourth Order.
Funds
1. “The anticancer activity of NGR modified micelles” National Natural Science Foundation of China in 2009-2011.
2. “Self-emulsifying drug delivery systems (SEDDS) for paclitaxel microemulsion” High Technology Project of Ministry of Science and Technology of China (863 Program) in 2004-2005.
3. “Pre-clinical research for ethaselen injection” High Technology Project of Ministry of Science and Technology of China (New drug Creating) in 2009-2010.
4. “CLA-PTX microemulsion” Fonder fund for new drug creating of Peking University Health Science Center in 2011-2012.
5. “iRGD modified liposomes” National Natural Science Foundation of China in 2012-2015.
6. Three technology transformation projects in drug formulation: paclitaxel microemulsion, teniposide microemulsion, DN-1 injection.
7. Take part:
two National Basic Research Program of China (973 Program) projects; two National Natural Science Foundation of China projects.
Selected publications:
1. Liu XR, Wu KC, Huang Y, Sun JB, Ke XY, Wang JC, Lu WL, Zhang X*, Zhang Q. In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions. Biol Pharm Bull. 2008 Jun; 31(6):1215-20.
2. Huang Y, Chen XM, Zhao BX, Ke XY, Zhao BJ, Zhao X, Wang Y, Zhang X*, Zhang Q. Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo. AAPS PharmSciTech. 2010 May 5; 11(2):752-9.
3. Ke XY, Zhao BJ, Zhao X, Wang Y, Huang Y, Chen XM, Zhao BX, Zhao SS, Zhang X*, Zhang Q. The therapeutic efficacy of conjugated linoleic acid - paclitaxel on glioma in the rat. Biomaterials. 2010 Aug; 31(22):5855-64.
4. Zhang X, Ogl？cka K, Sandgren S, Belting M, Esbj？rner EK, Nordén B, Gr？slund A.Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery. Biochim Biophys Acta. 2010 Dec; 1798(12):2201-8.
5. Zhao BJ, Ke XY, Huang Y, Chen XM, Zhao X, Zhao BX, Lu WL, Lou JN, Zhang X*, Zhang Q. The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats. J Drug Target. 2011 Jun;19(5):382-90.
6. Jia Z, Lin P, Xiang Y, Wang X, Wang J, Zhang X*, Zhang Q*. A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate. Eur J Pharm Biopharm. 2011 Sep;79(1):126-34.
7. Wang Y, Wu KC, Zhao BX, Zhao X, Wang X, Chen S, Nie SF, Pan WS, Zhang X*, Zhang Q. A novel paclitaxel microemulsion containing a reduced amount of Cremophor EL: pharmacokinetics, biodistribution, in vivo anti-tumor efficacy and safety. J Biomed Biotechnol. 2011;2011:854872.
8. Zhao BX, Zhao Y, Huang Y, Luo LM, Song P, Wang X, Chen S, Yu KF, Zhang X*, Zhang Q. The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel. Biomaterials. 2012 Mar;33(8):2508-20.
9. Zhao S, Dai W, He B, Wang J, He Z, Zhang X*, Zhang Q*. Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms. J Control Release. 2012 Mar 28;158(3):413-23.
10. Liu X, Sun J, Chen X, Wang S, Scott H, Zhang X*, Zhang Q. Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel delivered by polyvinylpyrrolidone solid dispersion. J Pharm Pharmacol. 2012 Jun;64(6):775-82.
11. Luo LM, Huang Y, Zhao BX, Zhao X, Duan Y, Du R, Yu KF, Song P, Zhao Y, Zhang X*, Zhang Q. Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel. Biomaterials. 2013 Jan;34(4):1102-14.
12. Li D, Yang K, Li JS, Ke XY, Duan Y, Du R, Song P, Yu KF, Ren W, Huang D, Li XH, Hu X, Zhang X*, Zhang Q. Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings. Int J Nanomedicine. 2012;7:6105-14.
13. Duan Y, Zhao X, Ren W, Wang X, Yu KF, Li D, Zhang X*, Zhang Q. Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation. Onco Targets Ther. 2013;6:189-98.
14. Yu KF, Zhang WQ, Luo LM, Song P, Li D, Du R, Ren W, Huang D, Lu WL, Zhang X*, Zhang Q. The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation. Int J Nanomedicine. 2013;8:2473-85.
15. Du R Zhong T, Zhang WQ, Song P, Song WD, Zhao Y, Wang C, Tang YQ, Zhang X*, Zhang Q. Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid-paclitaxel (CLA-PTX) on B16-F10 melanoma. Int J Nanomedicine. 2014 Jun 24;9:3091-3105.
16. Wang C, Wang X, Zhong T, Zhao Y, Zhang WQ, Ren W, Huang D, Zhang S, Guo Y, Yao X, Tang YQ, Zhang X*, Zhang Q. The antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR: in vitro and in vivo. Int J Nanomedicine. 2015 Mar 19;10:2229-48.
17. Zhang WQ, Yu KF, Zhong T, Luo LM, Du R, Ren W, Huang D, Song P, Li D, Zhao Y, Wang C, Zhang X*. Does ligand-receptor mediated competitive effect or penetrating effect of iRGD peptide when co-administration with iRGD-modified SSL? J Drug Target. 2015 Dec;23(10):897-909.
18. Zhao Y, Ren W, Zhong T, Zhang S, Huang D, Guo Y, Yao X, Wang C, Zhang WQ, Zhang X*, Zhang Q. Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity. J Control Release. 2016 Jan 28;222:56-66.
19. Huang D, Zhang S, Zhong T, Ren W, Yao X, Guo Y, Duan XC, Yin YF, Zhang SS, Zhang X*. Multi-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy. Oncotarget. 2016 Jul 12;7(28):43616-43628.
20. Song P, Yao X, Zhong T, Zhang S, Guo Y, Ren W, Huang D, Duan XC, Yin YF, Zhang SS, Zhang X*. The anti-tumor efficacy of 3-(2-Nitrophenyl) propionic acid-paclitaxel (NPPA-PTX): a novel paclitaxel bioreductive prodrug. Oncotarget. 2016 Jul 26;7(30):48467-48480.
21. Zhong T, Yao X, Zhang S, Guo Y, Duan XC, Ren W, Dan Huang, Yin YF, Zhang X*. A self-assembling nanomedicine of conjugated linoleic acid-paclitaxel conjugate (CLA-PTX) with higher drug loading and carrier-free characteristic. Sci Rep. 2016 Nov 4;6:36614.
22. Guo Y, Zhong T, Duan XC, Zhang S, Yao X, Yin YF, Huang D, Ren W, Zhang Q, Zhang X*. Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix. Drug Deliv. 2017 Nov;24(1):270-277.
23. Yin YF, Guo Y, Song WD, Duan XC, Zheng XC, Zhong T, Zhang S, Yao X, Xu MQ, Zhang Q, Zhang X*. Improving Solubility and Oral Bioavailability of Febuxostat by Polymer-Coated Nanomatrix. AAPS PharmSciTech. 2017 Oct 27. doi: 10.1208/s12249-017-0905-z.
24. Zhong T, Hao YL, Yao X, Zhang S, Duan XC, Yin YF, Xu MQ, Guo Y, Li ZT, Zheng XC, Li H, Zhang X*. The effect of XlogP and Hansen solubility parameters on small molecule modified paclitaxel anti-cancer drug conjugates self-assembled into nanoparticles. Bioconjug Chem. 2018 Jan 4. doi: 10.1021/acs.bioconjchem.7b00767.
