Biography

Prof. Dr. Wan-Liang Lu (Lyu) is Professor, Head of Department of Pharmaceutics, and Vice Dean of the School of Pharmaceutical Sciences at Peking University. He received his PhD degree from China Pharmaceutical University. He was a Research Scientist at National University of Singapore (NUS)/National University Hospital (NUH), Johns Hopkins Singapore International Medical Centre (2001-2003), and Toyama Medical & Pharmaceutical University (2004-2005). He is Associate Director of Pharmaceutics Specialty Committee at Chinese Pharmaceutical Association, the member of editorial board for Journal of Peking University (Health Sciences), Chinese Journal of Pharmaceutical Sciences, Asian Journal of Pharmaceutical Sciences, Chinese Pharmaceutical Journal and the referee for international peer-reviewed journals related to cancer research and pharmaceutical sciences. His research on cancer stem cells, multi-drug resistance of cancer, and biopharmaceutics resulted in 160 research papers. He was the recipient of Natural Science Award of China Education Ministry (the 1^st prize) in the year 2009 and 2012.

Research Interest

Cancer stem cells, Multidrug resistance of cancer, and Biopharmaceutics

Recent publications

1. Mu LM, Ju RJ, Liu R, Bu YZ, Zhang JY, Li XQ, Zeng F, Lu WL*. Dual-functional drug liposomes in treatment of resistant cancers. Adv Drug Deliv Rev. 2017 Jun 1;115: 46-56.

2. Liu L, Mu LM, Yan Y. Wu JS, Hu YJ, Bu YZ, Zhang JY, Liu R, Li XQ, Lu WL*. The use of functional epirubicin liposomes to induce programmed death in refractory breast cancer.Int J Nanomed. 2017 Jun 1;12:4163-4176.

3. Mu LM, Bu YZ, Liu L, Xie HJ, Ju RJ, Wu JS, Zeng F, Zhao Y, Zhang JY, Lu WL*. Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells. Sci Rep. 2017 Jun 14;7(1):3487

4. Zhao WY, Zhang CX, Liu L, Mu LM, Zeng F, Ju RJ, Xie HJ, Yan Y, Zhao Y. Lu WL*. Construction of functional targeting daunorubicin liposomes used for eliminating brain glioma and glioma stem cells. J Biomed Nanotech. 2016; 12(1):1-16.

5. Ju RJ, Li XT, Shi JF, Li XY, Sun MG, Zeng F, Zhou J, Liu L, Zhang CX, Zhao WY, Lu WL*. Liposomes, modified with PTDHIV-1 peptide, containing epirubicin and celecoxib, to target vasculogenic mimicry channels in invasive breast cancer. Biomaterials. 2014;35(26):7610-21.

6. Ma X, Zhou J, Zhang CX, Li XY, Li N, Ju RJ, Shi JF, Sun MG, Zhao WY, Mu LM, Yan Y, Lu WL*. Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes. Biomaterials.2013; 34(18):4452-65.

7. Li N, Zhang CX, Wang XX, Zhang L, Ma X, Zhou J, Ju RJ, Li XY, Zhao WY, Lu WL*. Development of targeting lonidamine liposomes that circumvent drug-resistant cancer by acting on mitochondrial signaling pathways. Biomaterials. 2013;34(13):3366-80

8. Zhang L, Yao HJ, Yu Y, Zhang Y, Li RJ, Ju RJ, Wang XX, Sun MG, Shi JF, Lu WL*. Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells. Biomaterials. 2012 Jan;33(2):565-82.

9. Li RJ, Ying X, Zhang Y, Ju RJ, Wang XX, Yao HJ, Men Y, Tian W, Yu Y, Zhang L, Huang RJ, Lu WL*. All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells. J Control Release. 2011; 149:281-291

10. Ying X, Wen H, Lu WL*, Du J, Guo J, Tian W, Men Y, Zhang Y, Li RJ, Yang TY, Shang DW, Lou JN, Zhang LR, Zhang Q. Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals. J Control Release. 2010; 141(2): 183-192