Liu Yan, Associate Professor, MS student supervisor

Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University

Xueyuan Rd 38，Beijing 100191

Tel: (+8610) 82801508

Email:yanliu@bjmu.edu.cn

    Received her bachelor (1986), master degree (1989) from Department of Chemistry of Shandong University. Worked in Beijing Medical University since 1989. Worked in University of Regensburg (Germany) as a visiting scholar during 1998-2000. Been working in Peking University since 2000. She has engaged herself in teaching of Physical Chemistry for undergraduate students, Physical Pharmaceutics for graduate students and Physical Chemistry of Dispersion System for doctorate students. Published more than 80 research papers and 11 textbooks or scholarly monographs. Granted 9 patents.

Research Interests

Physical Pharmaceutics

·Novel nanosized drug delivery system and targeted drug delivery

·Functional polymers and smart drug delivery system

·Drug polymorphism

Representative publications

1.Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Self-assembled nanoparticles from vitamin E succinate-based amphiphilic polymers for effective intestinal delivery of paclitaxel and their transcellular transport mechanisms and intracellular trafficking routes. Drug Delivery , 2018, 25(1):210-225.

2. Dishi Wang, Yanxia Zhou, Xinru Li, Yan Liu*, et al. Mechanisms of pH-sensitivity and cellular internalization of PEOz-b-PLA micelles with varied hydrophilic/hydrophobic ratios and intracellular trafficking routes and fate of the copolymer. ACS Applied Materials and Interfaces, 2017,9:6916-6930.

3. Ziqi Wang, Xinru Li, Dishi Wang, Yan Liu*, et al. Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with polymeric micelles. Acta Biomaterialia , 2017, 62:144-156.

4. Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Preparation and characterization of pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-vitamin E succinate for paclitaxel delivery. Journal of Chinese Pharmaceutical Sciences . 2017, 26(8): 582-588.

5. Yajie Gao, Yanfang Li, Yushu Li, Yan Liu*, et al. PSMA-mediated endosome escape-accelerating polymeric micelles for targeted therapy ofprostate cancerand the real time tracing of their intracellular trafficking. Nanoscale , 2015, 7(2):597-612.

6. Jinwen Li, Yanxia Zhou, Chengwei Li, Yan Liu*, et al. Poly(2-ethyl-2-oxazoline)-doxorubicin conjugate-based dual endosomal pH-sensitive micelles with enhanced antitumor efficacy. Bioconjugate Chemistry , 2015, 26(1):110-119.

7. Yong Zhao, Yanxia Zhou, Dishi Wang, Yan Liu*, et al. pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-gp inhibitor. Acta Biomaterialia , 2015,17:182-192.

8. Yajie Gao, Chao Zhang, Yanxia Zhou, Yan Liu*, et al. Endosomal pH-responsive polymer-based dual-ligand-modified micellar nanoparticles for tumor targeted delivery and facilitated intracellular releaseof paclitaxel. Pharmaceutical Research , 2015, 32(8):2649-2662.

9. Lei Zhao, Yanxia Zhou, Yajie Gao, Yan Liu*, et al.Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. International Journal of Pharmaceutics , 2015, 483:180-187.

10. Yajie Gao, Yanxia Zhou, Lei Zhao, Yan Liu*, et al. Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles. Acta Biomaterialia , 2015, 23:127-135.

11. Wenjing Li, Xinru Li, Yajie Gao, Yan Liu*, et al. The Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity. Molecular Pharmaceutics, 2014,11:71-80.

12. Chao Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Enhancedtopical delivery of tetrandrine by ethosomes for treatment of arthritis. Journal of Biomedicine and Biotechnology , 2013, Article ID 161943.

13. Na Li, Xinru Li, Yanxia Zhou, Yan Liu*, et al. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier. Biomaterials , 2012, 33(34):8881-8892.

14. Guiling Li, Yating Fan, Xinru Li, Yan Liu*, et al. In vitro and in vivo evaluation of a simple microemulsion formulation for propofol. International Journal of Pharmaceutics , 2012, 425:53–61.

15. Guiling Li, Chao Fan, Xinru Li, Yan Liu*, et al. Preparation and in vitro evaluation of tacrolimus loaded ethosomes. The Scientific World Journal , 2012, Article ID 874053.

16. Guiling Li, Yating Fan, Chao Fan, Yan Liu*, et al. Tacrolimus-loaded ethosomes: Physicochemical characterization and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics , 2012, 82:49-57.

17. Xingwei Chen, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization and in vivo evaluation. Journal of Biomaterials Applications , 2012, 27(4): 391-402.

18. Xiaoning Wang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels. Acta Biomaterialia , 2011, 7: 4149-4159.

19. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu*, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics , 2011, 407:158-166. 

20. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu*, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters , 2011, 6:275.

21. Yating Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. International Journal of Pharmaceutics, 2011, 416:323-330.

22. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid)  micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics , 2010, 7(4):1169-1182.

23. Wang Fei, Li Xinru, Zhou Yanxia, Yan Liu*, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics , 2010, 7(3):718-726.

24. Xinru Li, Pingzhu Li, Yan Liu*, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research , 2010, 27(8):1498-1511.

25. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu*, et al. Development of patch and spray formulations for enhancing topical delivery of   sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799.

26. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Preparation and evaluation of poly(ethylene glycol)–poly(Lactide) micelles as nanocarriers for oral Deliveryof cyclosporine A. Nanoscale Resrarch Letters , 2010, 5:917-925.

27. Xinru Li, Quan Yuan, Yanqing Huang, Yan Liu*, et al.Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech , 2010, 11(2):672-678.

28. Ming Chen, Xin-Ru Li, Yan-Xia Zhou,Yan Liu*, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes  through intranasal delivery. Peptides , 2009,30:1288-1295.

29. Kewei Yang, Xinru Li, Zhuoli Yang, Yan Liu*, et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization. Journal of Biomedical Materials Research Part A, 2009, 87(4):140-148.

30. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu*, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting , 2009, 17(10):739-750.

31. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu*, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters , 2009, 4:1502-1511.

32. Zhuoli Yang, Xinru Li, Kewei Yang, Yan Liu*. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: preparation, freeze-drying and in vitro release. Journal of Biomedical Materials Research Part A, 2008, 85(2):539-546.