Professor Xuan Zhang, PhD
Department of Pharmaceutics
School of Pharmaceutical Sciences
Peking University
Beijing 100191, China
Tel : +8610 8280 2683 (office)
Email: xuanzhang@bjmu.edu.cn
Received his bachelor (1990), master (1993) and doctor degree (1999) from Department of Pharmaceutical Sciences, China Pharmaceutical University.
Engaged in his postdoctoral fellow in School of Pharmaceutical Sciences, Peking University from 1999 to 2001.
As a visiting scholar in Stockholm University (Sweden 2004-2005) and Kyushu University (Japan 2006).
Been working in School of Pharmaceutical Sciences, Peking University since 2001.
He is engaged in teaching and research work of pharmaceutics. His teaching courses including pharmaceutics, biopharmaceutics and pharmacokinetics, pharmacy literature, advanced in pharmaceutics for undergraduate or graduate students.
Published more than thirty research papers and five 5 textbooks. Applied four patents, two of them have been authorized.
Editor of Journal of Chinese Pharmaceutical Sciences, Reviewer of some international journals.
Research interesting:
Targeting drug delivery system
Awards
1. “Novel drug delivery system” Science and Technology Progress Award from Chinese Pharmaceutical Association in 2008, First Prize, Second Order.
2. “Novel nano-drug delivery system” Award for Natural Sciences from Ministry of Education in 2004, Second Prize, Second Order.
3. “Novel protein drug delivery system” Award for Natural Sciences from Ministry of Education in 2002, Second Prize, Second Order.
4. “Long circulation liposomes for anti-cancer delivery system” Award for Natural Sciences from Ministry of Education in 2010, First Prize, Fourth Order.
Funds
1. “The anticancer activity of NGR modified micelles” National Natural Science Foundation of China in 2009-2011.
2. “Self-emulsifying drug delivery systems (SEDDS) for paclitaxel microemulsion” High Technology Project of Ministry of Science and Technology of China (863 Program) in 2004-2005.
3. “Pre-clinical research for ethaselen injection” High Technology Project of Ministry of Science and Technology of China (New drug Creating) in 2009-2010.
4. “CLA-PTX microemulsion” Fonder fund for new drug creating of Peking University Health Science Center in 2011-2012.
5. “iRGD modified liposomes” National Natural Science Foundation of China in 2012-2015.
6. Three technology transformation projects in drug formulation: paclitaxel microemulsion, teniposide microemulsion, DN-1 injection.
7. Take part:
two National Basic Research Program of China (973 Program) projects; two National Natural Science Foundation of China projects.
Selected publications:
1. Zhao BX, Zhao Y, Huang Y, Luo LM, Song P, Wang X, Chen S, Yu KF, Zhang X*, Zhang Q. The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel. Biomaterials. 2012 Mar;33(8):2508-20.
2. Zhao S, Dai W, He B, Wang J, He Z, Zhang X*, Zhang Q*. Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms. J Control Release. 2012 Mar 28;158(3):413-23.
3. Ke XY, Zhao BJ, Zhao X, Wang Y, Huang Y, Chen XM, Zhao BX, Zhao SS, Zhang X*, Zhang Q. The therapeutic efficacy of conjugated linoleic acid - paclitaxel on glioma in the rat. Biomaterials. 2010 Aug; 31(22):5855-64.
4. Jia Z, Lin P, Xiang Y, Wang X, Wang J, Zhang X*, Zhang Q*. A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate. Eur J Pharm Biopharm. 2011 Sep;79(1):126-34.
5. Zhao BJ, Ke XY, Huang Y, Chen XM, Zhao X, Zhao BX, Lu WL, Lou JN, Zhang X*, Zhang Q. The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats. J Drug Target. 2011 Jun;19(5):382-90.
6. Huang Y, Chen XM, Zhao BX, Ke XY, Zhao BJ, Zhao X, Wang Y, Zhang X*, Zhang Q. Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo. AAPS PharmSciTech. 2010 May 5; 11(2):752-9.
7. Zhang X, Oglęcka K, Sandgren S, Belting M, Esbjörner EK, Nordén B, Gräslund A.Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery. Biochim Biophys Acta. 2010 Dec; 1798(12):2201-8.
8. Liu XR, Wu KC, Huang Y, Sun JB, Ke XY, Wang JC, Lu WL, Zhang X*, Zhang Q. In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions. Biol Pharm Bull. 2008 Jun; 31(6):1215-20.
