Xueqing WangPh.D, A/Prof
Department of Pharmaceutics,
School of Pharmaceutical Sciences,
Peking University,
38 Xue Yuan Rd, Haidian Dist,
Beijing, 100191, P.R.China
Tel/Fax: 86-10-82805935
Email: wangxq@bjmu.edn.cn
Education:
2005.9-2008.7 Ph. D in Biophysics, State Key Lab of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China. (Supervisor: Prof. Rong-Qiao He)
2001.9-2003.7 M.S. in pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing, P.R. China. (Supervisor: Prof. Qiang Zhang)
1989.9-1993.7 B.S. in Pharmaceutical Science, School of Pharmaceutical Science, Beijing Medical University, Beijing, P.R. China.
Career:
2009.8- Associate Professor, School of Pharmaceutical Science, Peking University
1998.8-2009.7 Lecturer, School of Pharmaceutical Science, Peking University
1993.8-1998.7 Assistant,School of Pharmaceutical Science, Beijing Medical University
Research interests:
1. Nano-technology to improve the absorption of poor water soluble drugs and bioactive macromolecules.
2. Targeting drug delivery system for anticancer therapy.
Research projects participated：
1. Studies on the mechanism of novel preactivated thiomers in absorption enhancement of proteins and peptides (National Natural Science Foundation of China, 81273456)
2. Combined anticancer therapy based on molecular targeting drug delivery system. (key project of the National Natural Science Foundation of China, 81130059);
3. Improve the oral absorption of poor water soluble drugs using nanoparticle techniques. (973 projects of China, 2009CB930300);
4. Drug Delivery and Formulation Platform. (State Key Projects, 2009ZX09310-001);
5. Study on CyA nanomedicine to improve its oral absorption. (863 project, 2001AA218061, 2004AA218040);
6. Research of molecular pharmaceutics on carrier delivery system (key project of the National Natural Science Foundation of China, 30430760).
Selected Publications:
1. Qin Song, Xing Wang, Yaoqi Wang, Yanqin Liang, Yanxia Zhou, Xiaoning Song, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. Reduction responsive self-assembled nanoparticles based on disulfide-linked drug-drug conjugate with high drug loading and antitumor efficacy. Molecular Pharmaceutics. 2015, accepted.
2. Xianhui Chen, Yang Zhang, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, Qiang Zhang. The P-glycoprotein inhibitory effect and related mechanisms of thiolated chitosan and its S-protected derivative. RSC Advances. 2015 accepted
3. Hua Zhang, Hongxiang Hu, Haoran Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang* and Qiang Zhang*. Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis. Nanoscale. 2015, 7, 10790–10800.
4. Feiyang Deng, Chao Yu, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang*, Qiang Zhang. The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transportation in rats. Current Drug Delivery. On line 2015 Jul 22.
5. Qin Song, Xingxing Chuan, Binlong Chen, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells.Drug Delivery. DOI: 10.3109/10717544.2015.1028601
6. Hua Zhang, Youyou Zhao, Xueqing Wang*, and Qiang Zhang. Bioavailability of tramadol hydrochloride after administration via different routes in rats. Biopharmaceutics & Drug Disposition. 2014, 35: 525–531.
7. Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, and Qiang Zhang. Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)？Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo. Molecular Pharmaceutics. 2014, 11, 3656？3670.
8. Xueqing Wang, Suxin Li, Yujie Shi, Xingxing Chuan, Ji Li, Ting Zhong, Hua Zhang, Wenbing Dai, Bing He, Qing Zhang*.The development of site-specific drug delivery nanocarriers based on receptor mediation. Journal of Controlled Release. 2014, 193: 139–153.
9. Jingkai Lu, Xingxing Chuan, Hua Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang*, Qiang Zhang*. Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo.International Journal of Pharmaceutics. 2014, 471 (1-2) 525–535.
10. Chao Yu, Bing He, Meng-Hua Xiong, Hua Zhang, Lan Yuan, Ling Ma, Wen-Bing Dai, Jun Wang, Xing-Lin Wang, Xue-Qing Wang*, Qiang Zhang*, The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cell. Biomaterials. 2013，34 (26): 6284-6298.
11. Bo Zhao, Xue-Qing Wang*, Xiao-You Wang, Hua Zhang, Wen-Bing Dai, Jun Wang, Zhen-Lin Zhong, Hou-Nan Wu*and Qiang Zhang*. Nanotoxicity comparison of four amphiphilic polymeric micelles with similar hydrophilic or hydrophobic structure.Particle and Fibre Toxicology. 2013, 10:47.
12. Xueqing Wang, Javed Iqbal, Deni Rahmat, Andreas Bernkop-Schnürch*. Preactivated thiomers: Permeation enhancing properties.International Journal of Pharmaceutics. 2012, 438 (1-2): 217-224.
13.Xue-Qing Wang, Qiang Zhang*. pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics. 2012, 82 (2): 219-229.
14. Xue-qing Wang, Jie-ming Fan, Ya-ou Liu, Bo Zhao, Zeng-rong Jia, Qiang Zhang*. Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat. International Journal of Pharmaceutics. 2011, 419: 339-346.
15. Ya-Ou Liu, Jie-Ming Fan, Xue-Qing Wang*, Qiang Zhang. Preparation of sorafenib selfmicroemulsifying drug delivery system and its relative bioavailability in rats. Journal of Chinese Pharmaceutical Sciences. 2011, 20:164-170.
16.Wang Xueqing, Zhang Yuan, Pan Rong, He Rongqiao*, Distribution of earthworm fibrinolytic enzyme in rat gastrointestinal tract after oral administration. Chinese Journal of New Drugs. 2010, 19: 1360-1364.
17. Xue-Qing Wang, Lan Chen, Rong Pan, Jing Zhao, Ying Liu, Rong-Qiao He*, An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells. BMC biochemistry. 2008, 9:30 doi:10.1186/1471-2091-9-30.
18.Xue-Qing Wang, Jun-Dong Dai, Hua Zhang, Xuan Zhang,Jian-Cheng Wang, Qiang Zhang*.Absorption mechanism of cyclosporine A loaded pH-sensitive nanoparticles in rats. Journal of Nanoscience and Nanotechnology. 2008, 8:2422-2431.
19.Xue-qing Wang, Jia Huang, Jun-dong Dai, Tao Zhang, Wan-liang Lu,Hua Zhang, Xuan Zhang, Jian-cheng Wang, Qiang Zhang*. Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid.International Journal of Pharmaceutics. 2006,322:146 -153.
20.Xue-qing Wang, Jun-dong Dai, Zhen Chen, Tao Zhang, Gui-min Xia, Qiang Zhang*. Bioavailability and Pharmacokinetics of Cyclosporine A loaded pH-sensitive nanoparticles for oral administration. Journal of Controlled Release.2004, 97: 421-429.
21. Jun-dong Dai, Tsuneji Nagai, Xue-qing Wang, Tao Zhang, Meng Meng, Qiang Zhang*. pH-sensitive nanoparticles for improving the oral bioavailability of Cyclosporine A. International Journal of Pharmaceutics.2004,280: 229 -240.
22. Yuan Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Octreotide-Modified Polymeric Micelles as Potential Carriers for Targeted Docetaxel Delivery to Somatostatin Receptor Overexpressing Tumor Cells. Pharm Res. 2011, 28: 1167-1178.
23. Yu Xiang, Liang Liang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes. Journal of Controlled Release. 2011,152: 402-410.
24. Zengrong Jia, Ping Lin, Yu Xiang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate. European Journal of Pharmaceutics and Biopharmaceutics. 2011, 79: 126-134.
25. Junlin Zhang, Wu Jin, Xueqing Wang, Jiancheng Wang, Xuan Zhang and Qiang Zhang*. A Novel Octreotide Modified Lipid Vesicle Improved the Anticancer Efficacy of Doxorubicin in Somatostatin Receptor 2 Positive Tumor Models.Mol Pharm.2010, 7:1159-68.
26. Wu CS, Wang XQ, Meng M, Li MG, Zhang H, Zhang X, Wang JC, Wu T, Nie WH, Zhang Q*.Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats. J Microencapsul. 2010, 27:205-217.
27. Wenbing Dai, Tingyuan Yang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*.PHSCNK-Modified and doxorubicin-loaded liposomes as a dual targeting system to integrin-overexpressing tumor neovasculature and tumor cells. Journal of Drug Targeting.2009 (doi:10.3109/ 10611860903353354)。
Selected Patents:
1. Qing Zhang, Xue-Qing Wang, Jun-Dong Dai, Tian-Yan Zhou, Nanoparticles drug delivery system for oral administration（Patent No: ZL02153918.9）
2. Rong-Qiao He, Xue-Qing Wang, Lan Chen, Rong Pan, Rong Xiao. The application of EFNases in treating HBV infections. (Appl. No: 200810101356.9)
3. Xue-Qing Wang, Qiang Zhang, et al. Preparation and application of sorafenib self-microemulsifying drug delivery system for oral or infusion administration. (Appl. No:200910203734.9）
