Associate Professor Zhou Tianyan_

Tianyan Zhou, PhD, A/Professor

Department of Pharmaceutics

School of Pharmaceutical Sciences

Peking University

Beijing, 100191, P.R.China

Tel: 86-10-82805937

E-mail: tianyanzhou@bjmu.edu.cn

Tianyan Zhou received her Bachelor (1992), Master (1998) and PhD degree(2006) from School of Pharmaceutical Sciences, Beijing Medical University/Peking University, respectively.

She worked as lecturer (1999-2005) and associate professor (2005-) at Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University. She visited and worked in The Hong Kong Polytechnic University (2002-2004 ), and in Oklahoma State University (USA) (2007-2008) as a visiting scholar.

She is Member of Pharmacometrics Professional Committee of China, as well as the principle investigator on Natural Science Foundation of China Grant and the Grant for the Returned Overseas Scholars of Ministry of Education, the editorial board of Chinese Clinical Pharmacology and Therapeutics, and the referee for some journals related to pharmacokinetic/pharmacodynamic and cancer research sciences. She has published more than 60 research papers and 6 book chapters, and applied one patent. Her teaching courses involve biopharmaceutics and pharmacokinetics, advanced pharmacokinetics for undergraduates or graduates at Peking University.

Research Interests

1. Mechanism-based Pharmacokinetics/Pharmacodynamics modeling and simulation

2. Regulation mechanisms of drug metabolizing enzymes and their applications

Selected Publications

1. Xu, JJ; Wang, SY; Chen, Y; Chen, GP; Li ZQ; Shao, XY; Li, L; Lu, W; Zhou, TY*. Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. Acta Pharmacol Sin. 2014, In Press.

2. Li, XG; Zhao, ZG; Li, L; Zhou, TY*, and Lu, W*. Pharmacokinetics, in vitro and in vivo correlation, and efficacy of exenatide microspheres in diabetic rats. Drug Deliv. 2014, Early Online.

3. Ji, XW; Li, RT; Li, ZQ; Li, L; Shao, XY; Wang, SY; Yuan, Y; Zhou, TY*; Lu, W*. Inhibition of autophosphorylation of EGFR plays an important role in the anti-breast cancer efficacy of a dithiocarbamate derivative TM208. Acta Pharmacol Sin. 2014, 35, 239–247.

4. Li, MY; Li, HQ; Cheng, XL; Wang, XP; Li, L; Zhou, TY*, and Lu, W*. Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction between Erlotinib and Gemcitabine. Pharm Res. 2013, 30, 1400-1408.

5. Zhou, TY; Huang, CQ; Chen, Y; Xu, JJ; Shanbhag, PD; Chen, GP. Methamphetamine Regulation of Sulfotransferase 1A1 and 2A1 Expression in Rat Brain Sections. Neurotoxicology. 2013, 34, 212-218.

6. Wu, Q; Li, MY; Li, HQ; Deng, CH; Li, L; Zhou, TY*, and Lu, W*. Pharmacokinetic and pharmacodynamic study of erlotinib based upon phosphorylated epidermal growth factor receptor and tumor volume in human non-small cell lung cancer xenograft mouse mode. Acta Pharmacol Sin. 2013, 34, 1427–1436.

7. Cheng, XL; Guo,LP; Li, ZQ; Li, L; Zhou, TY*, Lu, W*. A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study. J Chromatogr B. 2013, 915–916, 64–70.

8. Zhou, TY; Chen, Y; Huang, CQ; Chen, GP. Caffeine induction of sulfotransferases in rat liver and intestine. J Appl Toxicol. 2012, 32, 804-809.

9. Zhou, X; Shang, DW; Zhang, TL; Li, L; Zhou, TY*; Lu, W*. Modeling of Angiotensin II-Angiotensin-(1-7) Counterbalance in Disease Progression in Spontaneously Hypertensive Rats Treated With/Without Perindopril. Pharmacol Res. 2012, 66, 177-184.

10. Li, XG; Li, L; Wang, XP; Ren, YP; Zhou, TY*; Lu, W*. Application of Model-Based Methods to Characterize Exenatide-Loaded Double-Walled Microspheres: In Vivo Release, Pharmacokinetic/Pharmacodynamic Model, and In Vitro and In Vivo Correlation. J Pharm Sci. 2012, 101, 3946-3961.

11. Xu, JJ; Chen, Y; Li, L; Li, ZQ; Wang, CA; Zhou, TY*, Lu, W*. An improved HPLC method for the quantitation of 3′-phosphoadenosine 5′-phosphate (PAP) to assay sulfotransferase enzyme activity in HepG2 cells. J Pharmaceut Biomed Analysis. 2012, 62, 182-186.

12. Ji, XW; Chen, Y; Li, RT; Zhou, TY*; Lu, W*. A high-sensitivity LC-MS/MS method for determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenylpropyl ester hydrochloride in rat plasma and its application to pharmacokinetics study. Biomed Chromatogr. 2012, 26, 1196-1201.

13. Li, XG; Li,L; Zhou,X; Chen,Y; Ren,YP; Zhou, TY*; Lu, W*. Pharmacokinetic/pharmacodynamic studies for exenatide in diabetic rats. Acta Pharmacol Sin. 2012, 33, 1379-1386.

14. Li, L; Li, ZQ; Deng, CH; Ning, MR; Li, HQ; Bi, SS; Zhou, TY* and Lu, W*. Mechanism-based Pharmacokinetic/Pharmacodynamic Model for CYP3A1/2 Induction by Dexamethasone in Rats. Acta Pharmacol Sin. 2012, 33, 127-136.

15. Li, MY; Wu, Q; Li, HQ; Ning, MR; Chen, Y; Li, L; Zhou, TY*; and Lu, W*. A high-sensitive LC-MS/MS method to determine the concentrations of erlotinib and its active metabolite OSI-420 in BALB/c nude mice simultaneously and its application to a pharmacokinetic study. J Chin Pharm Sci. 2012, 21, 296-303.

16. Chen, Y; Li, HQ; Xu, JJ; Jiu, XF; Deng, CH; Li, XG; Li, L; Xu, XQ; Zhou, TY*; and Lu, W*. Determination of metformin in diabetic rat plasma by an improved ion-pair high-performance liquid chromatography: Application to pharmacokinetic study, J Chin Pharm Sci. 2012, 21, 211-218.

17. Ning, MR; Li, L; Li, J; Li, ZQ; Li, RT; Zhou, TY*; Lu, W*. In-vitro screen of reversible and time-dependent inhibition of CYP3A by TM208 and TM209 in rat liver microsomes. Acta Pharm Sin B. 2012, 2, 179-185.

18. Shang, DW; Wang, XP; Zhao, XT; Huang, FM; Tian, GZ; Lu, W*; Zhou, TY*. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. J Chromatogr B. 2011, 879,　3459-3464．

19. Li, HQ; Li, MY; Li, ZQ; Li, L; Bi, SS; Deng, CH; Chen, R; Zhou,TY* and Lu, W*. New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines. Chin J Chem, 2011, 29, 1709-1714.

20. Jiu, XF; Shang, DW; Chen, Y; Li, XG; Wan, XM; Zhou, TY*; Lu, W*. A high performance liquid chromatography method for the quantitative determination assay of sitagliptin in rat plasma and its application in pharmacokinetics study. J Chin Pharm Sci. 2011, 20, 63-69.

21. Li, L; Li, ZQ; Li,HQ; Bi, SS; Li, Bo; Xu, JJ; Zhou, TY* and Lu, W*. Development of a quantitative real time PCR assay for absolute detection and quantification of CYP3A1 and CYP3A2 mRNA induction in rat liver. J Chin Pharm Sci. 2011, 20, 597-603.

22. Li, HQ; Chen, Y; Li, ZQ; Deng, CH; Li, L; Bi, SS; Li, MY; Zhou, TY*; Lu, W*. A high performance liquid chromatography method for the quantitative determination of erlotinib in the plasma of tumor bearing BALB/c nude mice and its application in a pharmacokinetic study. J Chin Pharm Sci. 2011, 20, 245-252.

23. Zhou, TY; Huang, CQ; Chen, Y; Shanbhag, PD; Chen, GP. Methamphetamine regulation of sulfotransferases in rat liver and brain. Am J Pharmacol Toxicol, 2010, 5, 125-132.

24. Zhou, TY; Li, XM; Ng, MTT; Wang, YF; Quek, NM; Luo, J; Yuan, WX; Tan, CH; Zeng, HQ; Li, TH. Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chem, 2009, 20, 644-647.

25. Zhou, TY; Wang, YF; Li, XM; Zhang, Q; Li, TH. Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. B Chem Soc Jpn, 2006, 79(8), 1300-1302.

26. Zhou, TY; Chen, GS; Wang, YF; Zhang, Q; Yang, M; Li, TH. Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Res.2004, 32, e173/1-e173/9.