何冰，研究员，博士生导师；国家级人才计划青年项目入选者；药剂学系；
电话/传真：010-82805935
电子邮箱：hebingmumu@bjmu.edu.cn
教育及科研工作经历
2019/8-至今，北京大学，药学院，研究员，预聘制助理教授/PI
2016/10-2019/8，北京大学，药学院，讲师
2013/7–2016/10，北京大学，基础医学院，博士后
2008/9–2013/7，北京大学，药剂学，理学博士
2005/9–2007/7，天津大学，制药工程，工学硕士
2001/9–2005/6，天津大学，制药工程，工学学士
主要研究方向
分子药剂学与纳米生物学，具体内容包括：
1. 纳米药物与机体(细胞/组织)相互作用的分子机理；
2. 利用系统生物学策略探究纳米药物体内转运机制；
3. 新型纳米疫苗体系构建及其免疫诱导效应研究。
何冰博士在国内外率先开始从纳米生物学角度开展纳米药物载体跨细胞转运机制的研究工作，揭示了一系列纳米药物特有的转运通路及调控规律，相关研究被国外专家评价为领域内“里程碑式(landmark)的研究”。近年来又率先将多组学技术应用于该领域，在国内外提出了纳米系统生物学的概念与策略，并建立了基于“纳米-邻近标记技术”的纳米-蛋白相互作用分析新方法，阐明了胞内蛋白花冠、高尔基体分泌小泡、Wnt-β-catenin信号通路等在纳米药物转运中的关键作用，逐步建立了具有自身特色的纳米药物研究体系。
何冰博士以第一或通讯作者在Advanced Drug Delivery Reviews、Nature Communications、Advanced Materials、Nano Today、ACS Nano、Biomaterials 、Theranostics、Nanoscale Horizons、Nanoscale、ACS Applied Materials & Interfaces、Asian Journal of Pharmaceutical Sciences等期刊上发表研究论文多篇。何冰博士目前担任中国药学会药剂学青年学者论坛专家委员会候补委员，并担任Asian Journal of Pharmaceutical Sciences杂志的青年编委。目前主持国家自然科学基金、北京市自然科学基金等多项基金，并作为研究骨干参与国家重点基础研究发展计划、国家自然科学基金重大项目等多项基金，同时作为负责人与国内龙头制药企业扬子江药业集团签定合作协议，通过校企合作推动创新纳米制剂的临床转化。
代表性论著
1. Zibin Zhang; Junji Ren; Wenbing Dai; Hua Zhang; Xueqing Wang; Bing He*; Qiang Zhang*; Fast and Dynamic Mapping of the Protein Corona on Nanoparticle Surfaces by Photocatalytic Proximity Labeling. Advanced Materials, 2023: 2206636. (IF 32.086)
2. Yuxi Cheng; Junji Ren; Peiyao Wu; Yuxing Lin; Shaojie Lan; Wenbing Dai; Xueqing Wang; Hua Zhang; Bing He*; Qiang Zhang*; Nanoparticulates reduce tumor cell migration through affinity interactions with extracellular migrasomes and retraction fibers, Nanoscale Horizons, 2022. 7: 779-789. (IF 11.684)
3. Mengmeng Qin#; Minghui Li#; Ge Song; Canyu Yang; Peiyao Wu; Wenbing Dai; Hua Zhang; Xueqing Wang; Yiguang Wang; Demin Zhou; Bing He*; Qiang Zhang*; Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination, Nano Today, 2021, 37: 101097. (IF 18.962)
4. Jian Zhang; Mengmeng Qin; Dan Yang; Lan Yuan; Xiajuan Zou; Wenbing Dai; Hua Zhang; Xueqing Wang; Bing He*; Qiang Zhang*; Nanoprotein Interaction Atlas Reveals the Transport Pathway of Gold Nanoparticles across Epithelium and Its Association with Wnt β-Catenin Signaling, ACS Nano, 2021, 15: 17977-17997. (IF 18.027)
5. Minghui Li#; Mengmeng Qin#; Ge Song; Hailiang Deng; Dakuan Wang; Xueqing Wang; Wenbing Dai; Bing He*; Hua Zhang*; Qiang Zhang*; A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens, Asian Journal of Pharmaceutical Sciences, 2020, 16: 97-109.(IF 9.273)
6. Qing Chen; Guannan Guan; Feiyang Deng; Dan Yang; Peiyao Wu; Shuangming Kang; Ruimeng Sun; Xiaoyou Wang; Demin Zhou; Wenbing Dai; Xueqing Wang; Hua Zhang;Bing He*; Dawei Chen*; Qiang Zhang*; Anisotropic active ligandations in siRNA-Loaded hybrid nanodiscs lead to distinct carcinostatic outcomes by regulating nano-bio interactions, Biomaterials, 2020, 251: 120008.(IF 15.304)
7. Mengmeng Qin; Jian Zhang; Minghui Li; Dan Yang; Dechun Liu; Siyang Song; Jijun Fu; Hua Zhang; Wenbin Dai; Xueqing Wang; Yiguang Wang; Bing He*; Qiang Zhang*; Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions, Theranostics, 2020, 10(3): 1213-1229. (IF 11.600)
8. Dan Yang#; Dechun Liu#; Hailiang Deng; Jian Zhang; Mengmeng Qin; Lan Yuan; Xiajuan Zou; Bin Shao; Huiping Li; Wenbin Dai; Hua Zhang; Xueqing Wang; Bing He*; Xing Tang*; Qiang Zhang*; Transferrin Functionization Elevates transcytosis of Nanogranules across Epithelium by Triggering Polarity-Associated Transport Flow and Positive Cellular Feedback Loop, ACS Nano, 2019, 13(5): 5058-5076. (IF 18.027)
9. Tongkai Chen#; Bing He#; Jingsong Tao; Yuan He; Hailiang Deng; Xueqing Wang*; Ying Zheng*; Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines, Advanced Drug Delivery Reviews, 2019, 143: 177-205.(IF 17.873)
10. Bing He; Yujie Shi; Yanqing Liang; Anpu Yang; Zhipu Fan; Lan Yuan; Xiajuan Zou; Xin Chang; Hua Zhang; Xueqing Wang; Wenbin Dai; Yiguang Wang; Qiang Zhang*; Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages, Nature Communications, 2018, 9: 2393. (IF 17.694)
11. Dan Yang#; Dechun Liu#; Mengmeng Qin; Binlong Chen; Siyang Song; Wenbing Dai; Hua Zhang; Xueqing Wang; Yiguang Wang; Bing He*; Xing Tang*; Qiang Zhang*; Intestinal Mucin Induces More Endocytosis but Less Transcytosis of Nanoparticles across Enterocytes by Triggering Nanoclustering and Strengthening the Retrograde Pathway, ACS Applied Materials & Interfaces, 2018, 10: 11443-11456. (IF 10.383)
12. Bing He; Lan Yuan; Wenbing Dai; Wei Gao; Hua Zhang; Xueqing Wang; Weigang Fang*; Qiang Zhang*; Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis, Nanoscale, 2016, 8(11): 6129-6145. (IF 8.307)
13. Chao Yu#; Bing He#; Menghua Xiong; Hua Zhang; Lan Yuan; Ling Ma; Wenbing Dai; Jun Wang; Xinglin Wang; Xueqing Wang*; Qiang Zhang*; The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cells, Biomaterials, 2013, 34(26): 6284-6298. (IF 15.304)
14. Bing He; Ping Lin; Zengrong Jia; Wenwen Du; Wei Qu; Lan Yuan; Wenbin Dai; Hua Zhang; Xueqing Wang; Jiancheng Wang; Xuan Zhang; Qiang Zhang*; The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells., Biomaterials, 2013, 34(25): 6082-6098. (IF 15.304)
15. Bing He; Zengrong Jia; Wenwen Du; Chao Yu; Yuchen Fan; Wenbing Dai; Lan Yuan; Hua Zhang; Xueqing Wang; Jiancheng Wang; Xuan Zhang; Qiang Zhang*; The transport pathways of polymer nanoparticles in MDCK epithelial cells, Biomaterials, 2013, 34(17): 4309-4326. (IF 15.304)
