首页» 师资队伍» 教授»
 
齐宪荣 教授
发布日期：2016-01-26 浏览次数： 字号：[ 大 中 小 ]

 

  

齐宪荣 博士教授  博士生导师

专业和研究方向: 药剂学

研究领域：药物递送系统的构筑、靶向化设计与评价，纳米技术

电话/传真:(10)-82801584   电子信箱：qixr@bjmu.edu.cn


 

 

1987年毕业于北京医科大学药学院后留校任教；1997年于日本星药科大学获药学博士学位，导师为永井恒司教授。现任北京大学药学院教授、博士生导师，中国药学会药剂专委会委员，北京药学会药剂专委会副主委，药物技术创新服务专委会副主委等。担任国家重点新产品计划，国家外国专家管理局千人计划、高端人才计划，国家自然科学基金，博士后科学基金，北京市中小企业创新基金等评审专家。

主持的基金项目包括教育部留学回国人员启动基金，国家自然科学基金，国家高技术研究发展计划（863计划），北京市自然科学基金，教育部博士点基金等，是北京大学创新药物大平台，新制剂与新释药系统技术平台，国家重点基础研究发展计划（973计划）的骨干成员。

获得的主要奖励包括Nagai Foundation；北京市科技进步奖（2001年）；教育部科技进步奖（1995年，2000年，2003年，2009年，2012年）；中国中西医结合学会科学技术奖（2007年）；中国药学会优秀论文二等奖（1999年）；中国药剂学会优秀论文一等奖（2002年）；药学学报优秀论文奖（2008年）；第四届北医大国际交流论文三等奖（1998年）；北京大学医学部教学优秀奖，SCI论文引用奖，发明专利奖等等。获北京大学优秀共产党员（2010年，2014年），药学院优秀共产党员（2009年）及第五届女教工之星等称号。

在国内外发表论文100余篇，教材与专著19部，获发明专利4项。指导多名学生获得国家奖学金、北京大学优秀博士论文等，培养博士和硕士学生50多人。教学课程包括本科生《药剂学》、《生物药剂学与药物动力学》以及研究生《药物递送系统》、《分子药剂学》等。

 

发表的部分论文：

  1. D.S. Liang, H.T. Su, Y.J. Liu, A.T. Wang, X.R. Qi*. Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-α-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers. Biomaterials 2015, 71, 11-23.
  2. W. Gao , T. Meng , N. Shi , H. Zhuang , Z. Yang , X.R. Qi*. Targeting and microenvironment responsive lipid nanocarrier for the enhancement of Targeting and Microenvironment-Responsive Lipid Nanocarrier for the Enhancement of Tumor Cell Recognition and Therapeutic Efficiency. Adv. Healthc. Mater. 2015, 4, 748–759.
  3. A. Wang, D. Liang, Y. Liu, X.R. Qi*. Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors. Biomaterials 2015, 53, 160-172.
  4. D. Dong, W. Gao, Y. Liu, X.R. Qi*. Therapeutic potential of targeted multifunctional nanocomplex co-delivery of siRNA and low-dose doxorubicin in breast cancer. Cancer Letters 2015, 359, 178–186.
  5. L. Sun, Y.J. Liu, Z.Z. Yang, X.R. Qi*. Tumor specific delivery with redox-1 triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization. RSC Advances, 2015, 5, 55566-55578.
  6. D.S. Liang, H.T. Su, Y.J Liu, A.T. Wang, X.R. Qi*. Enhance Cancer Cell Recognition and Overcome Drug Resistance Using Hyaluronic Acid and α-Tocopheryl Succinate Based Multifunctional Nanoparticles. Mol. Pharmaceutics, 2015, 12 (6), 2189–2202.
  7. Z.Z. Yang, J.Q. Li, Z.Z. Wang, D.W. Dong, X.R. Qi*. Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas. Biomaterials 2014, 35, 5226-5239.
  8. Z. Yang, B. Xiang, D. Dong, Z. Wang, J. Li, X.R. Qi*. Dual receptor-specific peptides modified liposomes as VEGF siRNA vector for tumor-targeting therapy. Current Gene Therapy. 2014, 4,289-299.
  9. N.Q. Shi*, X.R. Qi*, B Xiang, Y Zhang. A survey on“Trojan Horse”peptides Opportunities, issues and controlled entry to“Troy”.J. Control. Release 2014, 194, 53–70.
  10. K. Wu, Z.Z. Wang, D. Liu, X.R. Qi*. Pharmacokinetics, brain distribution, release and blood–brain barrier transport of Shunaoxin pills. J. Ethnopharmacol. 2014, 151, 1133-1140.
  11. W. Gao, B. Xiang, T. Meng, F. Liu, X.R. Qi *. Chemotherapeutic drug delivery to cancer cells using a combination of folate targeting and tumor microenvironment-sensitive polypeptides. Biomaterials. 2013, 34: 4137-4149.
  12. D. Dong, B. Xiang,W. Gao, Z. Yang, J. Li, X.R. Qi *. pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells. Biomaterials. 2013, 34: 4849-4859.
  13. B Xiang, D Dong, N Shi, W Gao, Z Yang, Y Cui, D Cao, XR Qi*. PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer. Biomaterials. 2013, 34: 6976-6991.
  14. D Dong, S Tong, XR Qi*. Comparative studies of polyethylenimine-doxorubicin conjugates with pH-sensitive and pH-insensitive linkers. J. Biomed. Mater. Res. 2013, 101A, 1336-1344.
  15. ZZ Yang, YQ Zhang, ZZ Wang, K Wu, JN Lou, XR Qi*. Enhanced brain distribution and pharmacodynamics of rivastigmine by liposomes following intranasal administration. Int. J. Pharm. 2013, 452, 344– 354.
  16. ZZ Yang, ZZ Wang, K Wu, XR Qi*. Tissue Distribution and Pharmacodynamics of Rivastigmine after Intranasal and Intravenous Administration in Rats. Current Alzheimer Res. 2012, 9(3), 315-325.
  17. SW Tong, B Xiang, DW Dong, XR Qi*. Enhanced antitumor efficacy and decreased toxicity by self-associated docetaxel in phospholipid-based micelles.Int. J. Pharm.2012, 434, 413– 419.
  18. NQ Shi, W Gao, B Xiang, XR Qi*. Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage. Int. J. Nanomed.2012, 7, 1613–1621.
  19. ZX Lv, LT Liu, XR Qi*. Development of small interfering RNA delivery system using PEI-PEG-APRPG polymer for antiangiogenic vascular endothelial growth factor tumor-targeted therapy. Int. J. Nanomed. 2011, 6, 1661-1673.
  20. DX Ma, NQ Shi, XR Qi*. Distinct transduction modes of arginine-rich cell-penetrating peptides for cargo delivery into tumor cells. Int. J. Pharm. 2011,419（1-2）, 200-208.
  21. W zhao, S Zhuang, XR Qi*. Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomes.Int. J. Nanomed. 2011, 6, 3087-3098.
  22. 王鹏程, 齐宪荣*. 可活化细胞穿膜肽的设计与酶解研究. 药学学报 2010, 45(8), 1048-1051.
  23. 马冬旭, 齐宪荣*.不同细胞系对细胞穿透肽的摄取与机制比较. 药学学报2010, 45(9), 1165-1169.
  24. Y Li, XR Qi*, Y Maitani, T Nagai. PEG–PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations. Nanotechnology 2009, 20, 055106.
  25. WX Ding, T Izumisawa, Y Hattori, XR Qi, D Kitamoto, Y Maitani. Non-ionic surfactant modified cationic liposomes mediated gene transfection in vitro and in the mouse lung. Biol Pharm Bull 2009, 32(2), 311-315.
  26. WX Ding, Y Hattori, XR Qi, Kitamoto Dai; Y Maitani. Surface properties of lipoplexes modified with mannosylerythritol lipid-A and tween 80 and their cellular association. Chem Pharm Bull 2009, 57(2), 138-143.
  27. HL Ma, XR Qi*, WX Ding, Y Maitani, T Nagai. Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles. J Biomed Mater Res 2008, 84A(3), 598-606.
  28. HL Ma, YF Xu, XR Qi*, Y Maitani, T Nagai. Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers.Int J Pharm 2008, 354 (1-2):217–226.
  29. HL Ma, XR Qi*, Y. Maitani, T. Nagai. Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate. Int. J. Pharm. 2007, 333:177–186.
  30. Y Zhang, XR Qi*, Y Gao, L Wei, Y Maitani, T Nagai. Mechanisms of co-modified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect. J Control Release 2007, 117, 281–290.
  31. WX Ding, XR Qi*, Q Fu, SX Piao. The pharmacokinetics and pharmacodynamics of sterylglucoside-modified liposomes for levonorgestrel delivery via nasal route. Drug Delivery 2007, 14, 101-104.
  32. XR Qi*, Y Yan, XD Ma, TY Li, XY Nie, BB Yang. Development of a local vasodilator delivery system using fibrin glue to prevent arterial graft from spasm. J Biomed Mater Res 2007,82A(1), 139–144.
  33. L Feng，XR Qi*, XJ Zhou, Y Maitani, SC Wang, Y Jiang, T Nagai. Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres. J Control Release 2006, 112(1), 35-42.
  34. XR Qi*, WW Yan, J Shi. Hepatocytes targeting of cationic liposomes modified with soybean sterylglucoside and polyethylene glycol. World J Gastroenterol 2005, 11(32), 4947-4952.
  35. WX Ding, XR Qi*, P Li, Y Maitani, T Nagai. Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-D. Int J Pharm 2005, 300, 38–47.
  36. J Shi, WW Yan. XR Qi*, Y Maitani, T Nagai. Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide. Drug delivery 2005, 12(6), 349-356.
  37. CJ Xiao, XR Qi*, Y Maitani, T Nagai. Sustained-release cisplatin from multivesicular liposomes:potentiation of antitumor efficacy against S180 murine carcinoma. J Pharm Sci 2004, 93(7), 1718-1724.
  38. XR Qi*, MH Liu, HY Liu,Y Maitani, T Nagai. Topical econazole delivery using liposomal gel. STP Pharm Sci 2003, 13(4), 241-245.
  39. SH Hwang, Y Maitani, XR Qi, K Takayama, Tsuneji Nagai. Remote loading of diclofenac, insulin and fluorescein isothiocyanate labeled insulin into liposomes by pH and acetate gradient methods.Int J Pharm 1999, 179, 85-95.
  40. K Shimizu, XR Qi, Y Maitani, M Yoshii, K Kawano, K Takayama, T Nagai. Targeting of soybean-derived sterylglucoside liposomes to liver tumors in rat and mice models.Biol Pharm Bull 1998, 21(7), 741-746.
  41. XR Qi, Y Maitani, T Nagai, SL Wei. Comparative pharmacokinetics and antitumor efficacy of doxorubicin encapsulated in soybean-derived sterols and poly(ethylene glycol) liposomes in mice. Int J Pharm 1997,146, 31-39.
  42. XR Qi, Y Maitani, T Nagai. Relation of rigidity of membrane and stability of dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols prepared by reverse-phase evaporation vesicle method. Chem Pharm Bull 1996, 44(1), 237-240.
  43. XR Qi, Y Maitani, T Nagai. Effect of soybean-derived sterols on the in vitro stability and the blood circulation of liposomes in mice.Int J Pharm 1995, 114, 33-41.
  44. XR Qi, Y Maitani, T Nagai. Rates of systemic degradation and reticuloendothelial system uptake of calcein in the dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols in mice. Pharm Res 1995, 12(1), 49-52.
  45. XR Qi, Y Maitani, N Shimoda, K Sakaguchi, T Nagai. Evaluation of liposomal erythropoietin prepared with reverse-phase evaporation vesicle method by subcutaneous administration in rats. Chem Pharm Bul 1995, 43(2), 295-299.
  46. Y Maitani, M Hazama, H Tojo, XR Qi, T Nagai. Effects of orally administered liposomes with soybean-derived sterols and their glucosides on rat body weight. Biol Pharm Bull 1995, 18(11), 1551-1555.
  47. XR Qi, Y Maitani, T Nagai. Relation of rigidity of membrane and stability of dipalmitoylphosphatidylcholine liposomes with soybean-derived sterols prepared by reverse-phase evaporation vesicle method.Chem Pharm Bull 1996, 44(1), 237-240.
 

 

 

 

 




打印本页 关闭窗口